PEGPH20

Date Title

Hingorani S.R., et al. Phase 1b Study of PEGylated Recombinant Human Hyaluronidase and Gemcitabine in Patients with Advanced Pancreatic Cancer; Clinical Cancer Research; 2016. 01/26/16

Shepard H.M. Breaching the Castle Walls: Hyaluronan-Depletion as a Therapeutic Approach to Cancer Therapy; Frontiers in Oncology; 2015. 09/28/15

Manuel E.R., et al. Salmonella-Based Therapy Targeting Indoleamine 2,3-Dioxygenase Coupled with Enzymatic Depletion of Tumor Hyaluronan Induces Complete Regression of Aggressive Pancreatic Tumor; Cancer Immunol Res; 2015. 07/01/15

Whatcott C.J., et al. Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer; Clinical Cancer Research; 2015. 02/18/15

Singha N.C., et al. Tumor-Associated Hyaluronan Limits Efficacy of Monoclonal Antibody Therapy; Molecular Cancer Therapeutics; 2015. 12/15/14

Jacobetz M.A., et al. Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer; Gut; 2012. 03/30/12

Provenzano P., et al. Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma; Cancer Cell; 2013. 03/20/12

Thompson C.B., et al. Enzymatic Depletion of Tumor Hyaluronan Induces Antitumor Responses in Preclinical Animal Models; Molecular Cancer Therapeutics; 2010. 10/26/10

Companion Diagnostic (CDx)

Date Title

ENHANZE^® Technology

Date Title

Jadin L., et al. Hyaluronan expression in primary and secondary brain tumors; Annals of Translational Medicine; 2015. 04/03/15

Jadin L., et al. Characterization of a Novel Recombinant Hyaluronan Binding Protein for Tissue Hyaluronan Detection; Journal of Histochemistry and Cytochemistry; 2014. 06/02/14

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